Biodiversidad microbiana en la producción del biofármaco L-asparaginasa: Una revisión sobre su potencial terapéutico
DOI:
https://doi.org/10.37768/unw.rinv.11.02.r0005Palabras clave:
L-asparaginasa, biodiversidad microbiana, biofármacoResumen
La leucemia linfoblastica aguda (LLA) es una neoplastia común en pediatría, en el Perú se reportan alrededor de 400 casos nuevos al año sólo en infantes. Dentro de los esquemas terapéuticos para tratar la LLA, la enzima L-asparaginasa de origen bacteriano es incluida como biofármaco de primera línea dentro de los principales protocolos de tratamiento. Sin embargo, la L-asparaginasa posee limitaciones que afectan su uso terapéutico y que son producto de su origen procariótico. En ese sentido, la búsqueda de nuevas versiones de la enzima con características cinéticas y estructurales obtenidas de microorganismos poco estudiados y aislados de ambientes inusuales se plantea como una oportunidad con alto potencial para suministrar biofármacos novedosos. Se concluye que la investigación en biodiversidad microbiana es una gran oportunidad de descubrir innumerables alternativas de L-asparaginasa con aplicaciones farmacéuticas de gran valor comercial.
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Derechos de autor 2022 Omar Santiago Pillaca-Pullo
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
