HDL colesterol, protector de enfermedad cardiovascular: calidad vs. cantidad
DOI:
https://doi.org/10.37768/unw.rinv.05.01.011Palabras clave:
HDL cholesterol, CETP (Cholesteryl ester transfer protein), coronary morbidity and mortality, reverse transport of cholesterol, number of particles HDL, HDL particles SizeResumen
Los estudios pioneros de Framingham mostraron una relación inversa entre los niveles bajos de HDL Colesterol y la morbilidad coronaria. Los ensayos con modificaciones en el estilo de vida han mostrado un muy discreto incremento en las cifras de HDL-C, y la intervención farmacológica con fibratos o acido nicotínico (niacina) no ha mostrado tampoco disminución de la mortalidad. Tratar a pacientes con medicamentos que afectan el transporte reverso de colesterol y que aumentan considerablemente la cifra de HDL tampoco ha logrado disminuir la morbilidad. La asociación inversa de cifras altas de HDL y mortalidad coronaria está siendo cuestionada en los últimos años y se ha comenzado a investigar la calidad del HDL o la de sus subfracciones como explicación a su actividad antiaterosclerótica.Métricas
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